Cancer is one of the most common diseases to threaten human health. If individuals with malignant tumors are screened via a single cell, medical workers are greatly advantageous to early diagnosis and intervention in malignant tumors therapy. Nowadays, prof. Chen Xianfeng group propose a fluorescence detection map to rapidly distinguish whether the chromosomes of cell are normal or abnormal by detection of fluorescent intensity of single cell. Herein, they draw a map from single cell with an abnormal number of chromosomes is monitored in real time. Moreover, this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer, which can achieve personalized cancer diagnosis and therapy. Therefore, cancer recurrences and metastasis can be effectively identified, utilizing this ultrasensitive detection method of abnormal chromosome number.

The research was published in “Hailang Dai^†, Hongrui Shan^†, Zhangchi Sun^†, Daopeng Dai, Yuxi Shang, Zhuangqi Cao, and Xianfeng Chen*, Single-cell detection by enhancement of fluorescence in waveguides for cancer diagnosis and therapy, Photonics Research, 9(12), 2381-2387 (2021)”。

Link: https://doi.org/10.1364/PRJ.435686